Архитектура системы прогнозирования состояния здоровья пациента с использованием методов агентного моделирования и машинного обучения
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Научный журнал Моделирование, оптимизация и информационные технологииThe scientific journal Modeling, Optimization and Information Technology
Online media
issn 2310-6018

Architecture of the patient's health predicting system using agent-based modeling and machine learning methods

idLisovenko A.S., idLimanovskaya O.V., idTarasov D.D., idMeshchaninov V.N., idGavrilov I.V.

UDC УДК 51-76
DOI: 10.26102/2310-6018/2024.47.4.016

  • Abstract
  • List of references
  • About authors

The introduction of information technology in medical institutions contributes to the development of predictive, preventive and personalized medicine. The task that arises in this case is to create a software analogue of the patient, capable of taking into account his individual indicators and predicting the state of health, is still relevant. The architecture of the patient's health predicting system presented in the work is aimed at solving this problem. A distinctive feature of the system architecture is the combination of the principles of agent modeling and representation of the patient's body in the form of interacting modules, which opens up wide opportunities for modeling the health status of the patient's body. The paper describes the hierarchy of agents in the system architecture, describes the rules of agent interaction and provides a mathematical model for evaluating the effectiveness of therapeutic effects on the patient's body, the solution of which is achieved through the interaction of system agents. The prediction of the patient's health status is performed using downloadable pre-trained machine learning models, while the models are directly involved in determining the behavior of agents. The architecture of the patient's health predicting system, implemented in the form of a software package, is a powerful tool for building agent-based predicting models aimed at modeling physiological and pathological processes and effects on the patient's body.

1. Lehrach H. Omics approaches to individual variation: modeling networks and the virtual patient. Dialogues in Clinical Neuroscience. 2016;18(3):253–265. https://doi.org/10.31887/DCNS.2016.18.3/hlehrach

2. Kutumova E., Kiselev I., Sharipov R., Lifshits G., Kolpakov F. Thoroughly Calibrated Modular Agent-Based Model of the Human Cardiovascular and Renal Systems for Blood Pressure Regulation in Health and Disease. Frontiers in Physiology. 2021;12. https://doi.org/10.3389/fphys.2021.746300

3. Day T.E., Ravi N., Xian H., Brugh A. An Agent-Based Modeling Template for a Cohort of Veterans with Diabetic Retinopathy. PLoS One. 2013;8(6). https://doi.org/10.1371/journal.pone.0066812

4. Veloso M. An agent-based simulation model for informed shared decision making in multiple sclerosis. Multiple Sclerosis and Related Disorders. 2013;2(4):377–384. https://doi.org/10.1016/j.msard.2013.04.001

5. Hum R.S., Kleinberg S. Replicability, Reproducibility, and Agent-based Simulation of Interventions. In: AMIA Annual Symposium Proceedings: American Medical Informatics Association Annual Symposium, AMIA 2017, 4–8 November 2017, Washington, USA. 2017. pp. 959–968.

6. Broomhead T., Ballas D., Baker S.R. Neighbourhoods and oral health: Agent-based modelling of tooth decay. Health & Place. 2021;71. https://doi.org/10.1016/j.healthplace.2021.102657

7. Li Y., Kong N., Lawley M.A., Pagán J.A. Using Systems Science for Population Health Management in Primary Care. Journal of Primary Care & Community Health. 2014;5(4):242–246. https://doi.org/10.1177/2150131914536400

8. Weston B., Fogal B., Cook D., Dhurjati P. An agent-based modeling framework for evaluating hypotheses on risks for developing autism: Effects of the gut microbial environment. Medical Hypotheses. 2015;84(4):395–401. https://doi.org/10.1016/j.mehy.2015.01.027

9. Auchincloss A.H., Diez Roux A.V. A New Tool for Epidemiology: The Usefulness of Dynamic-Agent Models in Understanding Place Effects on Health. American Journal of Epidemiology. 2008;168(1):1–8. https://doi.org/10.1093/aje/kwn118

10. Limanovskaya O.V. Imitatsionnoe modelirovanie v AnyLogic 7: v 2 chastyakh: Chast' 1. Yekaterinburg: Izdatel'stvo Ural'skogo universiteta; 2017. 152 p. (In Russ.).

11. Lisovenko A.S., Limanovskaya O.V., Gavrilov I.V., Meshchaninov V.N., Myakotnykh V.S. The concept of the agent-based model for predicting a patient’s general health in the process of aging. Modeling, Optimization and Information Technology. 2022;10(4). (In Russ.). https://doi.org/10.26102/2310-6018/2022.39.4.007

12. Neal M.L., Cooling M.T., Smith L.P. et al. A Reappraisal of How to Build Modular, Reusable Models of Biological Systems. PLoS Computational Biology. 2014;10(10). https://doi.org/10.1371/journal.pcbi.1003849

13. Tracy M., Cerdá M., Keyes K.M. Agent-Based Modeling in Public Health: Current Applications and Future Directions. Annual Review of Public Health. 2018;39:77–94. https://doi.org/10.1146/annurev-publhealth-040617-014317

14. Koshy-Chenthittayil S., Archambault L., Senthilkumar D., Laubenbacher R., Mendes P., Dongari-Bagtzoglou A. Agent Based Models of Polymicrobial Biofilms and the Microbiome–A Review. Microorganisms. 2021;9(2). https://doi.org/10.3390/microorganisms9020417

15. Limanovskaya O.V., Gavrilov I.V., Meshchaninov V.N., Lisovenko A.S. Building gender- and age-dependent models for assessing bio-age based on the functional data of the patient's body. Modeling, Optimization and Information Technology. 2024;12(2). (In Russ.). https://doi.org/10.26102/2310-6018/2024.45.2.012

Lisovenko Anton Sergeevich

Email: anton.lisovenko.researcher@mail.ru

ORCID |

Ural Federal University named after the first President of Russia B.N. Yeltsin

Yekaterinburg, Russian Federation

Limanovskaya Oksana Viktorovna
Ph.D. in Chemistry

ORCID |

Specialized Medical Care Center of Medical Cell Technology Institute
Ural State Medical University of the Ministry of Health

Yekaterinburg, Russian Federation

Tarasov Dmitry Dmitry
Ph.D. of Engineering Sciences

ORCID |


Yekaterinburg, Russian Federation

Meshchaninov Viktor Nikolaevich
Dr. of Medical Sciences, Professor

ORCID |

Ural State Medical University of the Ministry of Health
Laboratory of Anti-Aging Technologies of Specialized Medical Care Center of Medical Cell Technology Institute

Yekaterinburg, the Russian Federation

Gavrilov Iliya Valeriyavich
Candidate of Biological Sciences, Associate Professor

ORCID |

Ural State Medical University of the Ministry of Health
Laboratory of Anti-Aging Technologies of Specialized Medical Care Center of Medical Cell Technology Institute

Yekaterinburg, the Russian Federation

Keywords: health predicting, patient's health, agent-based modeling, patient's digital double, modular approach

For citation: Lisovenko A.S., Limanovskaya O.V., Tarasov D.D., Meshchaninov V.N., Gavrilov I.V. Architecture of the patient's health predicting system using agent-based modeling and machine learning methods. Modeling, Optimization and Information Technology. 2024;12(4). URL: https://moitvivt.ru/ru/journal/pdf?id=1724 DOI: 10.26102/2310-6018/2024.47.4.016 (In Russ).

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Full text in PDF

Received 22.10.2024

Revised 06.11.2024

Accepted 08.11.2024