Keywords: analysis of biomedical images, selection of objects, classification of nucleated cells, pattern recognition, oncohematology
A system for analyzing images of nucleated bone marrow cells for the formation of a diagnostic conclusion in oncohematology
UDC 004.932.2
DOI: 10.26102/2310-6018/2025.48.1.016
The paper presents a system for analyzing images of nucleated bone marrow cells to form a diagnostic conclusion in oncohematology, aimed at solving the problem of constructing a data processing pipeline in automatic analyzers of biomedical images. The relevance of the study is due to the need to improve the reliability of theof automatic microscopic analysis of biomedical samples, which is aa difficult task due to high variability and morphological complexity of the investigated objects. One solution to this problem is to develop a web service that uploads, processes and describes images, then classifies them into categories of confirmed and unconfirmed cases. This web service provides cross-platform and accessibility, builds an open database of verified images and providestools for processing and analyzing images, as well as tools for correcting by the physician of the processing results. The system does not prescribe treatment and does not make diagnoses in dependently, but serves as an intelligent tool for processing, analyzing and transmission of research results in real time. The testing results showed high accuracy of the system: 91% for neural network methods and up to 97% for classical algorithms. The developed system allows for the analysis of data processing modules for computer microscopy systems.
1. Kreiss L., Jiang S., Li X., Xu S., Zhou K.С., Lee K.С., Mühlberg A., Kim K., Chaware A., Ando M., Barisoni L., Seung A.L., Zheng G., Lafata K.J., Friedrich O., Horstmeyer R. Digital staining in optical microscopy using deep learning – a review. PhotoniX. 2023;4. https://doi.org/10.1186/s43074-023-00113-4
2. Yao J., Huang X., Wei M., Han W., Xu X., Wang R., Chen J., Sun L. High-Efficiency Classification of White Blood Cells Based on Object Detection. Journal of Healthcare Engineering. 2021;2021. https://doi.org/10.1155/2021/1615192
3. Medovy V.S., Volkov G.D., Strela N.M., Pervushkin I.V. An Adaptable Cloud-Based Multiple-Unit Laboratory Microscopy System. Biomedical Engineering. 2021;55:36–40. https://doi.org/10.1007/s10527-021-10066-2
4. Samorodov A.V. Biotechnological Systems for Automated Microscopy of Cytology Specimens. Biomedical Engineering. 2019;52(6):387–390. https://doi.org/10.1007/s10527-019-09853-9
5. Polyakov E.V. A study of noise characteristics on images in computer microscopy systems. Transactions TSTU. 2020;26(4):598–603. (In Russ.).
6. Dmitrieva V.V., Tupitsyn N.N., Polyakov E.V., Nosova E.M., Palladin A.D., Tsyplyak V.I., Liberis K.A. Medical information system based web technologies for the diagnosis of acute lymphoblastic leukemia and minimal residual disease. IT Security (Russia). 2021;28(3):44–55. (In Russ.). https://doi.org/10.26583/bit.2021.3.03
7. Fazeli S., Samiei A., Lee T.D., Sarrafzadeh M. Beyond Labels: Visual Representations for Bone Marrow Cell Morphology Recognition. In: 2023 IEEE 11th International Conference on Healthcare Informatics (ICHI), 26–29 June 2023, Houston, USA. IEEE; 2023. pp. 111–117. https://doi.org/10.1109/ICHI57859.2023.00025
8. Deshpande N.M., Gite S., Aluvalu R. A review of microscopic analysis of blood cells for disease detection with AI perspective. PeerJ Computer Science. 2021;7. https://doi.org/10.7717/peerj-cs.460
9. Yildirim M., Çinar A. Classification of White Blood Cells by Deep Learning Methods for Diagnosing Disease. Revue d'Intelligence Artificielle. 2019;33(5):335–340.
10. Dehkharghanian T., Mu Y., Ross C., Sur M., Tizhoosh H.R., Campbell C.J.V. Cell projection plots: A novel visualization of bone marrow aspirate cytology. Journal of Pathology Informatics. 2023;14. https://doi.org/10.1016/j.jpi.2023.100334
11. Cheng Z., Li Y. Improved YOLOv7 Algorithm for Detecting Bone Marrow Cells. Sensors. 2023;23(17). https://doi.org/10.3390/s23177640
12. Polyakov E.V., Tupitsyn N.N., Serebryakova I.N., Palladina A.D.; pravoobladatel' federal'noe gosudarstvennoe avtonomnoe obrazovatel'noe uchrezhdenie vysshego obrazovaniya "Natsional'nyi issledovatel'skii yadernyi universitet "MIFI" (NIYaU MIFI). Baza dannykh kletok kostnogo mozga bol'nykh ostrym limfoblastnym leikozom: zayavka No. 2023620945: zayavl. 06.04.2023: opubl. 20.04.2023. Svidetel'stvo o gosudarstvennoi registratsii bazy dannykh No. 2023621283 Rossiiskaya Federatsiya. (In Russ.).
Keywords: analysis of biomedical images, selection of objects, classification of nucleated cells, pattern recognition, oncohematology
For citation: Polyakov E.V., Popov V.V., Dmitrieva V.V. A system for analyzing images of nucleated bone marrow cells for the formation of a diagnostic conclusion in oncohematology. Modeling, Optimization and Information Technology. 2025;13(1). URL: https://moitvivt.ru/ru/journal/pdf?id=1796 DOI: 10.26102/2310-6018/2025.48.1.016 (In Russ).
Received 10.01.2025
Revised 03.02.2025
Accepted 05.02.2025