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<article article-type="research-article" dtd-version="1.3" xml:lang="ru" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xsi:noNamespaceSchemaLocation="https://metafora.rcsi.science/xsd_files/journal3.xsd">
  <front>
    <journal-meta>
      <journal-id journal-id-type="publisher-id">moitvivt</journal-id>
      <journal-title-group>
        <journal-title xml:lang="ru">Моделирование, оптимизация и информационные технологии</journal-title>
        <trans-title-group xml:lang="en">
          <trans-title>Modeling, Optimization and Information Technology</trans-title>
        </trans-title-group>
      </journal-title-group>
      <issn pub-type="epub">2310-6018</issn>
      <publisher>
        <publisher-name>Издательство</publisher-name>
      </publisher>
    </journal-meta>
    <article-meta>
      <article-id pub-id-type="doi"/>
      <article-id pub-id-type="custom" custom-type="elpub">270</article-id>
      <title-group>
        <article-title xml:lang="ru">ОДНОФАКТОРНЫЙ ДИСПЕРСИОННЫЙ АНАЛИЗ ВЛИЯНИЯ НЕКОТОРЫХ ФАКТОРОВ НА КАЧЕСТВО СНА ПРИ ХОБЛ И НА ФОНЕ ДЕЙСТВИЯ МЕЛАТОНИНА</article-title>
        <trans-title-group xml:lang="en">
          <trans-title>ONE-WAY ANALYSIS OF VARIANCE OF SOME FACTORS INFLUENCE ONTHE SLEEP QUALITY IN COPD AND UNDER MELATONIN ACTION</trans-title>
        </trans-title-group>
      </title-group>
      <contrib-group>
        <contrib contrib-type="author" corresp="yes">
          <name-alternatives>
            <name name-style="eastern" xml:lang="ru">
              <surname>Цветикова</surname>
              <given-names>Любовь Николаевна</given-names>
            </name>
            <name name-style="western" xml:lang="en">
              <surname>Tsvetikova</surname>
              <given-names>Lyubov' Nikolaevna</given-names>
            </name>
          </name-alternatives>
          <xref ref-type="aff">aff-1</xref>
        </contrib>
        <contrib contrib-type="author" corresp="yes">
          <name-alternatives>
            <name name-style="eastern" xml:lang="ru">
              <surname>Кудашова</surname>
              <given-names>Евгения Александровна</given-names>
            </name>
            <name name-style="western" xml:lang="en">
              <surname>Kudashova</surname>
              <given-names>Evgenia Alexandrovna</given-names>
            </name>
          </name-alternatives>
          <xref ref-type="aff">aff-2</xref>
        </contrib>
        <contrib contrib-type="author" corresp="yes">
          <name-alternatives>
            <name name-style="eastern" xml:lang="ru">
              <surname>Василенко</surname>
              <given-names>Дмитрий Викторович</given-names>
            </name>
            <name name-style="western" xml:lang="en">
              <surname>Vasilenko</surname>
              <given-names>Dmitry Viktorovich</given-names>
            </name>
          </name-alternatives>
          <xref ref-type="aff">aff-3</xref>
        </contrib>
        <contrib contrib-type="author" corresp="yes">
          <name-alternatives>
            <name name-style="eastern" xml:lang="ru">
              <surname>Будневский</surname>
              <given-names>Андрей Валериевич</given-names>
            </name>
            <name name-style="western" xml:lang="en">
              <surname>Budnevsky</surname>
              <given-names>Andrei Valerievich</given-names>
            </name>
          </name-alternatives>
          <xref ref-type="aff">aff-4</xref>
        </contrib>
        <contrib contrib-type="author" corresp="yes">
          <name-alternatives>
            <name name-style="eastern" xml:lang="ru">
              <surname>Овсянников</surname>
              <given-names>Евгений Сергеевич</given-names>
            </name>
            <name name-style="western" xml:lang="en">
              <surname>Ovsyannikov</surname>
              <given-names>Evgeny Sergeevich</given-names>
            </name>
          </name-alternatives>
          <xref ref-type="aff">aff-5</xref>
        </contrib>
        <contrib contrib-type="author" corresp="yes">
          <name-alternatives>
            <name name-style="eastern" xml:lang="ru">
              <surname>Попова</surname>
              <given-names>Анна Николаевна</given-names>
            </name>
            <name name-style="western" xml:lang="en">
              <surname>Popova</surname>
              <given-names>Anna Nikolaevna</given-names>
            </name>
          </name-alternatives>
          <email>an_popova@mail.ru</email>
          <xref ref-type="aff">aff-6</xref>
        </contrib>
      </contrib-group>
      <aff-alternatives id="aff-1">
        <aff xml:lang="ru">Воронежский государственный медицинский университет им. Н.Н. Бурденко</aff>
        <aff xml:lang="en">Voronezh State Medical University named after N.N. Burdenko</aff>
      </aff-alternatives>
      <aff-alternatives id="aff-2">
        <aff xml:lang="ru">Воронежский государственный медицинский университет им. Н.Н. Бурденко</aff>
        <aff xml:lang="en">Voronezh State Medical University named after N.N. Burdenko</aff>
      </aff-alternatives>
      <aff-alternatives id="aff-3">
        <aff xml:lang="ru">Воронежский государственный медицинский университет им. Н.Н. Бурденко</aff>
        <aff xml:lang="en">Voronezh State Medical University named after N.N. Burdenko</aff>
      </aff-alternatives>
      <aff-alternatives id="aff-4">
        <aff xml:lang="ru">Воронежский государственный медицинский университет им. Н.Н. Бурденко</aff>
        <aff xml:lang="en">Voronezh State Medical University named after N.N. Burdenko</aff>
      </aff-alternatives>
      <aff-alternatives id="aff-5">
        <aff xml:lang="ru">Воронежский государственный медицинский университет им. Н.Н. Бурденко</aff>
        <aff xml:lang="en">Voronezh State Medical University named after N.N. Burdenko</aff>
      </aff-alternatives>
      <aff-alternatives id="aff-6">
        <aff xml:lang="ru">Воронежский государственный медицинский университет им. Н.Н. Бурденко</aff>
        <aff xml:lang="en">Voronezh State Medical University named after N.N. Burdenko</aff>
      </aff-alternatives>
      <pub-date pub-type="epub">
        <day>01</day>
        <month>01</month>
        <year>2026</year>
      </pub-date>
      <volume>1</volume>
      <issue>1</issue>
      <elocation-id>e270</elocation-id>
      <permissions>
        <copyright-statement>Copyright © Авторы, 2026</copyright-statement>
        <copyright-year>2026</copyright-year>
        <license license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/">
          <license-p>This work is licensed under a Creative Commons Attribution 4.0 International License</license-p>
        </license>
      </permissions>
      <self-uri xlink:href="https://moitvivt.ru/ru/journal/article?id=270"/>
      <abstract xml:lang="ru">
        <p>Однофакторный дисперсионный анализ позволил выявить негативную&#13;
взаимосвязь гендерной принадлежности, возраста, продолжительности заболевания,&#13;
никотиновой зависимости, количества госпитализаций и количества обострений с&#13;
обращением к специалисту в год, уровня тревожности и депрессии, теста ТШХ и&#13;
качеством сна у пациентов с умеренной степенью развития хронической&#13;
обструктивной болезни легких (ХОБЛ). Прием мелатонина (по схеме) пациентами с&#13;
умеренной степенью развития ХОБЛ приводит к статистически значимому&#13;
повышению уровня качества сна, снижению количества обострений с вызовом врача&#13;
общей практики, скорой медицинской помощи или госпитализации на фоне улучшения&#13;
психоэмоционального состояния. Однако данная схема приема мелатонина для&#13;
пациентов с тяжелым течением ХОБЛ не приводит к эффективной коррекции&#13;
нарушений</p>
      </abstract>
      <trans-abstract xml:lang="en">
        <p>Оne-way analysis of variance revealed the negative impact of gender, age, duration of&#13;
disease, nicotine addiction, the number of hospitalizations and the number of exacerbations&#13;
with an appeal to the person skilled in the year, the level of anxiety and depression, TSHH the&#13;
quality of sleep in patients with moderate development of chronic obstructive pulmonary&#13;
disease (COPD). Acceptance of melatonin (the scheme) patients with moderate COPD leads&#13;
to statistically zanchimomu improving sleep quality, reduce the number of exacerbations with&#13;
the call of a general practitioner, emergency medical care and hospitalization in the&#13;
background to improve the psycho-emotional sostoyaniya. Odnako this regimen of melatonin&#13;
in patients with severe COPD does not lead to effective correction of sleep disorders</p>
      </trans-abstract>
      <kwd-group xml:lang="ru">
        <kwd>хобл</kwd>
        <kwd>мелатонин</kwd>
        <kwd>бессонница</kwd>
        <kwd>качество жизни</kwd>
        <kwd>однофакторный дисперсионный анализ</kwd>
      </kwd-group>
      <kwd-group xml:lang="en">
        <kwd>copd</kwd>
        <kwd>melatonin,</kwd>
        <kwd>insomnia</kwd>
        <kwd>quality of life</kwd>
        <kwd>one-way analysis of variance</kwd>
      </kwd-group>
      <funding-group>
        <funding-statement xml:lang="ru">Исследование выполнено без спонсорской поддержки.</funding-statement>
        <funding-statement xml:lang="en">The study was performed without external funding.</funding-statement>
      </funding-group>
    </article-meta>
  </front>
  <back>
    <ref-list>
      <title>References</title>
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    <fn-group>
      <fn fn-type="conflict">
        <p>The authors declare that there are no conflicts of interest present.</p>
      </fn>
    </fn-group>
  </back>
</article>